共查询到18条相似文献,搜索用时 93 毫秒
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二唑衍生物具有抗菌、消炎和调节植物生长等活性[1~5].二唑硫醚衍生物也具有一定抗菌活性[6].为筛选具有生物活性的新化合物和研究亲核取代反应的规律,我们设计和合成了新的2-酰肼基-5-(2,4-二氯苯基)-1,3,4-二唑2,研究了2在K2C... 相似文献
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1,3,4-(口恶)二唑类化合物具有广泛的生物生理活性,如杀菌[1]、除草[2]、杀虫[3]和消炎[4]等,而2,5-二芳基-1,3,4-(口恶)二唑类化合物一般具有昆虫生长调节活性,1980年美国Dow公司报道了2,5-双(2,4-二氯苯基)-1,3,4-(口恶)二唑具有良好的昆虫生长调节活性[5]. 相似文献
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异噁唑衍生物作为一类重要的生物活性物质[1,2],其合成一直受到人们的关注,其中德国HMR公司开发研制的新型抗内风湿性关节炎药来氟米特(Leftunomide)已于1998年在美国率先上市,该药还具有很好的免疫调节作用[3].7H-均三唑[3,4-b]-1,3,4-噻二嗪、咪唑并[2,1-b]噻唑和咪唑并[2,1-b]-1,3,4-噻二唑衍生物均表现出广谱的生物活性[4~6]. 相似文献
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2-氨基-5-取代-1,3,4-噻二唑与2-氯代-1-(2,4-二氯苯基)乙酮的反应研究 总被引:1,自引:0,他引:1
2-氨基-5-烷基/芳基1,3,4-噻二唑与2-氯代-1-(2′,4′-二氯苯基)乙酮在热乙醇中反应生成一系列2-烷基/芳基-6-(4,4-二氯)苯基咪唑并[2-1-b]-1,3,4-噻二唑.产物通过元素分析, IR, 1H NMR, 13C NMR及MS分析,化合物5g的X衍射晶体结构分析表明,产物的芳基是在咪唑并[2-2-b]-1,3,4-噻二唑的6-位而不在5-位. 相似文献
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改进了邻溴苯基-2-(口恶)唑啉的合成方法,使得N-(β-羟乙基)-2-(口恶)溴苯甲酰胺在氯化亚砜作用下缩合成唑啉的收率从40%左右提高到84%,并避免了使用NaH试剂,为芳基-2-(口恶)唑啉的合成提供一条方便、经济的路线.实验结果表明,反应温度对唑啉的收率的影响显著,随着反应温度的升高收率明显降低,室温下几乎得不到目标产物.根据实验结果推测其反应过程是经过互变异构酰亚胺中间物Ⅰ进行的. 相似文献
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Synthesis of 4-amino-2-aryl(or alkyl)amino-5-cinnamoylthiazoles by a [(C ─ N ─ C ─ S) + C] ring construction route is reported. Unlike the analogous 2′-aminochalcones, neither do these thiazoles cyclize to bicyclic pyridones, nor could these be prepared from the corresponding 5-acetylthiazoles and benzaldehyde. 相似文献
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A. Shafiee I. Lalezari M. Mirrashed D. Nercesian 《Journal of heterocyclic chemistry》1977,14(4):567-571
A series of 5-substituted-2-(4-alkyl or phenyl-1,2,3-thia(or selena)diazol-5-yl)-1,3,4-oxadiazoles were prepared. 5-Substituted-2-(4-phenyl-1,2,3-selenadiazol-5-yl)-1,3,4-oxadiazoles upon pyrolysis afforded the corresponding alkynes. Also, a series of 5-substituted-4-amino-3-(1,2,3-thiadiazol-5-yl)-s-triazoles and 5-(1,2,3-thiadiazolyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles were prepared. 相似文献
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2-(4-Decarboxydehydroabietyl)-5-p-toyl-[1,3,4]-oxadiazole, C28H34N2O, has been synthesized and characterized by IR, NMR, elemental analysis and single-crystal X-ray diffraction method. The crystal belongs to the orthorhombic system, space group P212121 with a = 6.1351(5), b = 14.8495(19), c = 25.9050(2) A, V = 2360.0(4) A3, Z = 4, Mr = 414.57, Dc = 1.167 Mg/m^3, 2 = 0.71073 A,μ(MoKa) = 0.070 mm^-1, F(000) = 896, the final R = 0.0452 and wR = 0.1076 for 1647 observed reflections with I 〉 2σ(I). There are five rings in the crystal structure of the title compound, but the oxadiazole ring is non-coplanar with the benzene ring D. 相似文献
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Yu-Tao Zheng Teng-Teng Zhang Pei-Yi Wang Zhi-Bing Wu Lei Zhou Yi-Qiang Ye Xiang Zhou Ming He Song Yang 《中国化学快报》2017,28(2):253-256
By introducing the pyrazole moiety into the 5-position of 1,3,4-oxadiazole,a series of novel 2-(thioether/sulfone)-5-pyrazolyl-l,3,4-oxadiazole derivatives were synthesized.Preliminary bioassays suggested that target compounds exhibited appreciable activity against pathogenic bacteria Xanthomonas oryzae pv.oryzae(Xoo) and five phytopathogenic fungi in vitro.Among them,the half-maximal effective concentration(EC_(50)) values of 6c,7a,7b and 7c against Xoo were within 16.6 μg/mL and 65.7 μg/mL,which were better than those of commercial agricultural antibacterial bismerthiazol(92.6 μg/mL) and thiodiazole copper(121.8 μg/mL).While compounds 7a,7b,and 7c exerted comprehensive antifungal activity toward five plant fungi,which were comparable with that of hymexazol.The results demonstrated that this kind of compounds can be further studied and developed as promising antifungal and antibacterial agents. 相似文献
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Mikhailov I. E. Artyushkina Yu. M. Dushenko G. A. Minkina V. I. 《Russian Chemical Bulletin》2020,69(1):176-178
Russian Chemical Bulletin - 2-Aryl-5-methyl-1,3,4-oxadiazoles were synthesized by reflux of equimolar amounts of acyl hydrazides with triethyl orthoacetate in o-xylene. The obtained oxadiazoles,... 相似文献
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Yasuo Saegusa Yasuhiro Ozeki Shigeo Nakamura 《Macromolecular rapid communications》1996,17(10):667-673
A novel thermally stable and semiconducting polyheterocycle, poly(1,3,4-oxadiazole amine), was synthesized from 2-(p-aminophenyl)-1,3,4-oxadiazolin-5-one via ring-opening. The polymer is a new class of ordered alternating copoly(aniline) containing 1,3,4-oxadiazole heterocyclic units. The polymer is highly thermally stable and exhibits no weight loss up to 370°C in air. Its electric conductivity is less than 10−10 S · cm−1 at ambient temperature, but markedly increases to 6,5 · 10−7 S · cm−1 upon doping with iodine. 相似文献