共查询到20条相似文献,搜索用时 0 毫秒
1.
In order to find antitumoral agents, a number of new N-(4-pyrimidyl) ethylamine derivatives have been synthesized from 4,6-dichloropyrimidine, 6-amino-4-chloropyrimidine, 4-chloro-6-hydroxypyrimidine, and various ethylamines substituted in the position. 相似文献
2.
In order to find antitumoral substances, a number of new derivatives of N-(4-pyrimidyl)ethylamine with an allyl or p-chlorophenyl group in position 5 of the pyrimidine nucleus has been synthesized. The starting materials were 5-allyl-4, 6-dichloropyrimidine and 5-(p-chlorophenyl)-4, 6-dichloropyrimidine and various ethylamines substituted in the -position.For part I, see [1]. 相似文献
3.
John L. LaMattina 《Journal of heterocyclic chemistry》1983,20(3):533-538
A general synthetic scheme for the preparation of 2-amino-4,(4-imidazolyl)pyridines, potential histamine H2 antagonists, is described. The synthesis is based on the Neber rearrangement of l,(4-pyridyl)l-alkanone oxime 0-tosylates to the appropriate α-aminoketones or α-aminoketals, which are then converted to the corresponding imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of chloride by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates. 相似文献
4.
5.
Ohne ZusammenfassungHerrn Prof. Dr.E. Ziegler zum 60. Geburtstag gewidmet. 相似文献
6.
7.
An alternate synthesis of 1-(2,4-dichlorophenyl)-4-(2-imidazolyl)-1-butanones 5d is presented after 1-[(dimethylamino)methyl- and 1-methyl]-2-lithioimidazole failed to be substituted satisfactorily by 2-(2,4-dichlorophenyl)-2-(3-iodopropyl)-1,3-dioxolane ( 3b ). The Pinner addition of ethanol to 2-(2,4-dichlorophenyl)-2-(3-cyanopropyl)-1,3-dioxolane yielded the corresponding imidate which was reacted with 1-amino-2,2-dimethoxyethane to form an amidine. Hot dilute hydrochloric acid converted this ami-dine to the 2-imidazolyl ketone 5b . Syntheses of homologous 1-(4-chloro- and 2,4-dichlorophenyl)-4-(2-imidazolyl)-1-pentanones 20 are described. Ketalizations of 5 and 20 with glycerol formed imidazolyl 1,3-dioxolanyl alcohols. Selective N- and O-alkylations of some of these imidazolyl alcohols are described. 相似文献
9.
In reaction of N,N-dichloro-4-chlorobenzene- and N,N-dichloro-4-methylbenzenesulfonamides with phenylacetylene were obtained in good yield N-(2-benzene-2,2-dichloroethylidene)arenesulfonamides. The latter undergo nucleophilic addition of water, ethanol, and arenesulfonamides. 相似文献
10.
Mathieu Toumi 《Tetrahedron letters》2010,51(47):6126-6128
A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4,4-dimethoxy-2-butanone and amidines, which provides acetyl-imidazoles and late stage palladium-catalyzed N-arylation to give the target pyrimidine derivatives. 相似文献
11.
12.
13.
Douglas X. West Authrine C. Whyte Fatimah D. Sharif Haileselassie Gebremedhin Anthony E. Liberta 《Transition Metal Chemistry》1993,18(2):238-242
Summary NiII and CuII complexes of 2-acetylpyridine 4
N-(2-methylpyridinyl)-, 4
N-(2-ethylpyridinyl)- and 4
N-methyl(2-ethylpyridinyl) thiosemicarbazones (HL4pam, HL4pae, and HL4Mpae, respectively) of general formula [M(HL)X2] have been isolated from boiling EtOH and characterized by physico-chemical and spectroscopic methods. The growth inhibition activities of the thiosemicarbazones and their complexes were measured against Aspergillus nicer and Paecilomyces variotii. 相似文献
14.
Reaction of methyllithium with 1-methy1-2-imidazolecarboxaldehyde afforded the corresponding alcohol 2. Oxidation of compound 2 with manganese dioxide gave 2-acety1-1-methylimidazole ( 3 ). Using compound 3 and substituted isatins 4 , the corresponding quinoline-4-carboxylic acids ( 5 ) were prepared. The reaction of acid imidazolides of 5 with appropriate amines yielded the amides 6 . Carbamic acid esters 10 were prepared by the Curtius rearrangement in good yield. Substituted quinolin-4-amines 13 were obtained by the acid hydrolysis of compound 10 (R1 = t-Bu). Alkylation of amines 13 with diakylaminoalkyl chlorides gave compounds 14 . 相似文献
15.
The Claisen-Schmidt condensation of 1-(triphenylmethyl)-2-imidazolecarboxaldehyde with acetophenones yielded 1-aryl-3-[1-(triphenylmethyl)-2-imidazolyl]propen-1-ones 7 . Selective catalytic hydrogenation over platinum of 7 furnished 1-aryl-3-(2-imidazolyl)-1-propanones 8 . An alternate synthesis of 8 started with sodium borohydride reduction of 7 to give allylic alcohols, 1-aryl-3-[1-(triphenylmethyl)-2-imidazolyl]-2-propen-1-ols 10 , which were rearranged by hot aqueous sodium to 8 . Acid hydrolysis of 8 provided the title compounds and triphenylmethanol. 相似文献
16.
S. L. Gurina R. Kh. Batulina L. V. Alekseeva Z. V. Pushkareva 《Chemistry of Heterocyclic Compounds》1968,4(3):321-321
N-[4-(2-Naphthyl)]-(IIa) and N-[4-(2-thienyl)methylaminobenzoyl]-dl-glutamic acids (IIb) have been synthesized for biological tests by the reaction of the corresponding halogen derivatives with diethyl p-aminobenzoyl-dl-glutamate (III) with subsequent hydrolysis of the esters obtained. 相似文献
17.
18.
19.