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《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》1988,44(10):981-983
The macrocyclic condensed aromatic hydrocarbon C40H20 cyclo[d.e.d.e.e.d.e.d.e.e] decakisbenzene is treated. It belongs to the class of cycloarenes. The simple Hückel molecular orbital analysis has been performed and employed in the construction of a harmonic force field. The set of calculated vibrational frequencies is reported. 相似文献
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G. F. Makhaeva V. L. Yankovskaya V. I. Fetisov V. B. Sokolov V. V. Malygin I. V. Martynov 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4)
Abstract The interaction of insecticides (RO)2P (0)OCH (CF3) COOCK3 (I) and (RO)2P(0)SCH(X)COOC2H5 (X=Cl(II), Br(III); R=Me, Et, Pr, i-Pr, Bu, i-Bu, Am, Hex) with acetylcnolinesterase (ACnE), butyrylcholinesterase (BChE) and carboxylesterase (CE) was studied in connection with their role in organo-phosphate toxicity mechsnisms. Toxicity of I–III to mice was determined. I–III were not hydrolysed by CE and irreversibly inhibited all the enzymes, II, IIi had a greater inhibitory potency compared to I: lgkII AChE = 2–4 (I), 6 (II, III); lgkII BChE = 3–6 (I), 5–8 (II, III); lgkII CE = 3–7 (I), more than 8 (II, III). With multiple regression analysis the dependence of antienzymatic activity on hydrophobicity and steric properties of alkyl substituents was investigated. The contribution of the hydrophobic interactions to dChE and CE (enzymes-“sites of loss”) inhibition was the same and more significant than that to AChE (target enzyme) inhibition. Steric effects are more important in AChE inhibition. The dependences lg(I/LD50) = f(ΓΠ) for I–III were in great extent determined by binding with nonspecific esterases that rises with increasing hydrophobicity. These results indicate that nonspecific esterases CE and BChE play a buffer role in toxic action of I and especially II and III. 相似文献
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QSAR Studies on the Toxicity of Nitrobenzenes to Population Growth of Tetrahymena Pyriformis 总被引:1,自引:0,他引:1
XU Jing bo ** JING Ti song Pauli W. Berger S. . Department of Environmental Science Northeast Normal University Changchun P.R.China . College of Environment Resource Jilin University Changchun P.R. China 《高等学校化学研究》2002,18(3)
IntroductionMost ofnitroaromatics are main environmentalpollutants.Those industrial chemicals have a highexposure to the aquatic ecosystems,especially inthe region of the Songhua River.Many quantitativestructure- activity relationships ( QSARs) havebeen developed to predict the toxicity of organicchemicals to environmentally important species[1] .QSARs have been developed for predicting thenitroaromatic compounds′ toxicity to aquaticspecies too[2— 5] . The most successful QSARs arethos… 相似文献
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《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》1988,44(10):975-979
Some topological properties of coronoids are given. These systems have chemical counterparts in cycloarenes. For one of these molecules, viz. C48H24 kekulene, the simple Hückel molecular orbital analysis has been performed and employed in the construction of a harmonic force field. Finally the set of calculated vibrational frequencies is reported. 相似文献
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1 INTRODUCTION Nitrobenzenes are an important class of industrial chemicals produced with substantial marketing volu-mes and a diverse range of use patterns[1].They are widely used as pesticides,solvents,explosives,dye-stuffs,etc.Most of the nitrobenzenes together with their derivatives are toxic,and they can cause dam-nification of human kidney,liver,eye,skin,blood system and so on[2~4].It is reported that all nitro-benzenes and their metabolites have mutagenicity,which induces the cyto… 相似文献
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Tomer Babu Hiba Ghareeb Dr. Uttara Basu Hemma Schueffl Dr. Sarah Theiner Prof. Petra Heffeter Prof. Gunda Koellensperger Prof. Norman Metanis Prof. Valentina Gandin Prof. Ingo Ott Dr. Claudia Schmidt Prof. Dan Gibson 《Angewandte Chemie (International ed. in English)》2023,62(10):e202217233
AuI-carbene and PtIV−AuI-carbene prodrugs display low to sub-μM activity against several cancer cell lines and overcome cisplatin (cisPt) resistance. Linking a cisPt-derived PtIV(phenylbutyrate) complex to a AuI-phenylimidazolylidene complex 2 , yielded the most potent prodrug. While in vivo tests against Lewis Lung Carcinoma showed that the prodrug PtIV(phenylbutyrate)-AuI-carbene ( 7 ) and the 1 : 1 : 1 co-administration of cisPt: phenylbutyrate: 2 efficiently inhibited tumor growth (≈95 %), much better than 2 (75 %) or cisPt (84 %), 7 exhibited only 5 % body weight loss compared to 14 % for 2 , 20 % for cisPt and >30 % for the co-administration. 7 was much more efficient than 2 at inhibiting TrxR activity in the isolated enzyme, in cells and in the tumor, even though it was much less efficient than 2 at binding to selenocysteine peptides modeling the active site of TrxR. Organ distribution and laser-ablation (LA)-ICP-TOFMS imaging suggest that 7 arrives intact at the tumor and is activated there. 相似文献
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Axel Dietrich 《Nachrichten aus der Chemie》1998,46(6):660-661
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Zusammenfassung Durch Anwendung der vonF. Kröhnke
1 ausgearbeiteten Methode zur Darstellung von -Keto-carbonsäuren konnte man über die roten Anile VIII die entsprechenden -Keto-(3,4,5-trimethoxyphenyl)-alkancarbonsäuren (IX, XI) gewinnen. Die erfolgreich durchgeführte Synthese des -(p-Dimethylaminophenylimino)--keto--(3,4,5-trimethoxyphenyl)-valeriansäurenitrils (VIIIc) läßt auch die geplante Synthese von -(p-Dimethylaminophenylimino)--keto--[2,3,4,4-tetramethoxydiphenylyl-(6)]-valeriansäurenitril und der entsprechenden -Keto-säure (V, [H statt Br]) als hoffnungsvoll erscheinen. 相似文献
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Afterourarticletitled“Hydrothermalsyntheses ,supramolecularstructuresandthethird ordernon linearopticalpropertiesofthreecopper(I)halideaminecom plexesconnectedviasecondarybondinginteractions”ispublishedinChineseJournalofChemistry 2 0 0 2 ,2 0 ,85 1— 85 7,anadvicefro… 相似文献
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Zusammenfassung Bei der Spaltung des -(p-Dimethylaminophenylimino)--keto--(3,4,5-trimethoxyphenyl)-valeriansäurenitrils (V) mit Chlorwasserstoffsäure entsteht die -Keto--(3,4,5-trimethoxyphenyl)-buttersäure (VII) und nicht, wie infolge des Versagens einiger typischen -Ketocarbonsäurereaktionen vermutet wurde, die 3-Hydroxy-4,5,6-trimethoxy-indan-3-carbonsäure.1. Mitt.:J. Michalský undL. Sadílek, Mh. Chem.90, 171 (1959). 相似文献