Functional Data Model for Genetically Related Individuals With Application to Cow Growth

We propose a new version of functional data model for analyzing familial related individuals, where the within-subject correlation depends smoothly on a covariate such as age and the between-subject correlation follows family-wise genetic association. Our motivating example concerns measurements of weight as a function of age in sibling cows from independent families. Observations are sparsely sampled from trajectories of a phenotype contaminated with measurement error, where the phenotypic trajectory consists of a genetic component and an environmental component. By combining information across individuals, the genetic and environmental covariances are estimated via smoothing techniques. We study the genetic and environmental effects using principal component analysis, taking into account the genetic correlation to enhance the subject-level signal extraction. We show via the real data and simulations that incorporating the correlation structure improves predictions of individual phenotypic trajectories.     

Massively Parallel Nonparametric Regression,With an Application to Developmental Brain Mapping

A penalized approach is proposed for performing large numbers of parallel nonparametric analyses of either of two types: restricted likelihood ratio tests of a parametric regression model versus a general smooth alternative, and nonparametric regression. Compared with naïvely performing each analysis in turn, our techniques reduce computation time dramatically. Viewing the large collection of scatterplot smooths produced by our methods as functional data, we develop a clustering approach to summarize and visualize these results. Our approach is applicable to ultra-high-dimensional data, particularly data acquired by neuroimaging; we illustrate it with an analysis of developmental trajectories of functional connectivity at each of approximately 70,000 brain locations. Supplementary materials, including an appendix and an R package, are available online.     

Explaining functional principal component analysis to actuarial science with an example on vehicle insurance

Given the high competitiveness in the vehicle insurance market, the need arises for an adequate pricing policy. To this end, insurance companies must select risks in a way that allows the expected claims ratio to come as close as possible to the real claims ratio. The use of new analytical tools which provide more information is of great interest. In this paper it is shown how functional principal component analysis can be useful in actuarial science. An empirical study is carried out with data from a Spanish insurance company to estimate the risk of occurrence of a claim in terms of the driver’s age, whilst taking into account other relevant variables.     

Detecting Change Points in Polynomial Regression Models with an Application to Cable Data Sets

In this paper, the Schwarz Information Criterion (SIC) is used to detect the change points in polynomial regression models. Switching quadratic regression models with same amount of model deviation and switching polynomial regression models with different amount of model deviation for different segments of regression are considered. The number of separate regimes and their corresponding regression orders are assume to be known. The method is then applied to cable data sets and the change points are successfully detected.     

The Accumulated Persistence Function,a New Useful Functional Summary Statistic for Topological Data Analysis,With a View to Brain Artery Trees and Spatial Point Process Applications

We start with a simple introduction to topological data analysis where the most popular tool is called a persistence diagram. Briefly, a persistence diagram is a multiset of points in the plane describing the persistence of topological features of a compact set when a scale parameter varies. Since statistical methods are difficult to apply directly on persistence diagrams, various alternative functional summary statistics have been suggested, but either they do not contain the full information of the persistence diagram or they are two-dimensional functions. We suggest a new functional summary statistic that is one-dimensional and hence easier to handle, and which under mild conditions contains the full information of the persistence diagram. Its usefulness is illustrated in statistical settings concerned with point clouds and brain artery trees. The supplementary materials include additional methods and examples, technical details, and the R code used for all examples.