共查询到20条相似文献,搜索用时 23 毫秒
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Mei-Jun Chu Xu-Li Tang Guo-Fei Qin Nicole J. de Voogd Ping-Lin Li Guo-Qiang Li 《中国化学快报》2017,28(6):1210-1213
Three new non-brominated pyrrole alkaloids,nakamurines A-C(1-3) were isolated from the South China Sea sponge Agelas nakamurai.Their structures were elucidated on the basis of spectroscopic data.Compound 2 showed weak antimicrobial activity against Candida albicans with MIC of 60μg/mL. 相似文献
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Tao Li Ping-Lin Li Xiang-Chao Luo Xu-Li Tang Guo-Qiang Li 《Tetrahedron letters》2019,60(30):1996-1998
Three new dibromopyrrole alkaloids, 9-N-methylcylindradine A (1), 1-N-methylugibohlin (2), nemoechine H (3), together with one known dibromopyrrole alkaloid N-methyldibromoisophakellin (4) were isolated from the South China Sea sponge Agelas nemoechinata. Their structures were elucidated by comprehensive spectroscopic methods including HRESIMS and NMR, and the absolute configuration of compound 1 was further confirmed by comparison of optical rotation. Compound 3 exhibited moderate cytotoxic activity against K562 and L-02 with IC50 values of 6.1 μM and 12.3 μM, respectively. 相似文献
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Ya-Ting Sun Bin Lin Sheng-Ge Li Man Liu Yong-Jun Zhou Ying Xu Hui-Ming Hua Hou-Wen Lin 《Tetrahedron》2017,73(19):2786-2792
Chemical investigation of the marine sponge Agelas sp. collected from the South China Sea resulted in the isolation of four new dimeric bromopyrrole alkaloids, including hexazosceptrin (1) with a rare cyclohexane-fused-cyclobutane skeleton, agelestes A and B (2–3), the sceptrin analogues without any aminoimidazole substitution, and (9S, 10R, 9′S, 10′R)-nakamuric acid (4), of which the absolute configuration was confirmed for the first time. The structure elucidation and absolute configuration assignments were unambiguously determined via extensive spectroscopic analyses and the comparison of experimental and calculated electronic circular dichroic spectra. Compounds 1 and 4 exhibited moderate antimicrobial activity. 相似文献
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Yang Qing He Xiao Mei Wei Yi Li Han Li Ming Gao 《中国化学快报》2007,18(5):545-547
Chemical investigation on the ethanol extract from the whole plants of Delphinium chrysotrichum resulted in the isolation of two new diterpene alkaloids named delphatisine A (1) and delphatisine B (2), respectively. The structures of the new compounds were deduced on the basis of their spectral data (IR, HREIMS, EIMS, 1D, 2D-NMR). This is the first report on the isolation of diterpenoid alkaloids from the D. chrysotrichum. 相似文献
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SU Jing-Yu ZHONG Yong-Li ZENG Long-MeiDepartment of Chemistry Zhongshan University Guangzhou Guangdong China WU Hou-Ming MA KanState Key Laboratory of Bioorganic Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China 《中国化学》1995,13(5):460-463
A new sesquiterpene, ent-furodysin (1), has been isolated from the South China Sea Sponge Dysidea fragilis, along with a known sesqui-terpene, ent-furodysinin (2). The structure and relative stereochemistry of 1 and 2 were established by spectral analysis. 相似文献
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A new steroid, (3S,5R,9R,10S,13R,17R,20R,24S,22E)-ergosta-6,8,22-triene-3,25-diol (1), and its sulfonated analogue (2) together with a known one, 5α,8α-epidioxy-cholest-6-en-3β-ol (3) were isolated from the marine sponge Dactylospongia elegans collected from the South China Sea. The new structures including absolute configurations were established by the HRESIMS and 1D and 2D NMR analysis coupled with the X-ray crystal analysis. Both of 1 and 2 exhibited cytotoxicity against cancer cell line MCF-7 with IC50 values of 9.7 and 8.5 μM, respectively. 相似文献
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Zhongbin Cheng Dong Liu Nicole J. de Voogd Peter Proksch Wenhan Lin 《Helvetica chimica acta》2016,99(8):588-596
Chemical examination of a marine sponge Xestospongia sp. resulted in the isolation of 20 sterol derivatives ( 1 – 20 ), including eight new sterols namely aragusterols J – L ( 1 – 3 ), (5α,7α,12β,22E)‐7,12,18‐trihydroxystigmast‐22‐en‐3‐one ( 4 ), (5α,7α,12β,24R)‐ and (5α,7α,12β,24S)‐7,12,20‐trihydroxystigmastan‐3‐one ( 5 / 6 ), and (5α,7α,12β,22E,24R)‐ and (5α,7α,12β,22E,24S)‐7,12,20‐trihydroxyergost‐22‐en‐3‐one ( 7 / 8 ). The structures of new compounds were determined through extensive spectroscopic analyses and chemical conversion. The sterol diversity was mainly characterized by the presence of a cyclopropane unit at side chain, while compound 4 with 18‐hydroxymethyl group was found in stigmasterol family for the first time. Cytotoxic test revealed the inhibitory effects of compounds 1 , 4 , and 17 against human leukemia cell line K562 with IC50 values of 18.3, 24.1, and 34.3 μm , respectively. 相似文献
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Takaaki KubotaTakahiro Iwai Azusa Takahashi-NakaguchiJane Fromont Tohru GonoiJun'ichi Kobayashi 《Tetrahedron》2012,68(47):9738-9744
New diterpene alkaloids, agelasines O-U (1-7), have been isolated from an Okinawan marine sponge Agelas sp. The gloss structures and relative stereochemistries of 1-7 were elucidated from the spectroscopic data. Agelasines O-R (1-4) were the third examples of diterpene alkaloid with a 9-N-methyladenine and a pyrrole units. Agelasine O (1) has a halimane skeleton, while agelasines P-R (2-4) have a clerodane skeleton. Agelasines S-U (5-7) were new diterpene alkaloids with a 9-N-methyladenine unit consisting of a halimane skeleton, a labdane skeleton, and a clerodane skeleton, respectively. Agelasines O-R (1-4) and T (6) showed antimicrobial activities against several bacteria and fungi. 相似文献
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海绵的代谢产物中含有多种多样结构新异的生理活性物质[1~ 4 ] ,从中发现了不少抗肿瘤、抗病毒的活性物质 .我们在系统地研究海绵次生代谢产物的生理活性物质中 ,从海绵 Ircinia selagineaL amarck(Dictyoceratida目 ,Thorectidae科 )中分离出一种结构罕见的长共轭二萜烯酮 (1 ) . 1是新化合物 ,命名为 irciniketene,采用波谱方法测定了其化学结构 (Scheme 1 ) .生物活性试验表明 ,化合物 1对肿瘤细胞具有较强的抑制作用 .1 21 31 4 1 5 011 11 92 01 89871 7654 31 6C2 C1 OScheme1 Structure of irciniketene( 1 )1 实验部分1 .1 … 相似文献
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《Analytical letters》2012,45(1):204-212
This study investigated the distribution and concentrations of chromium, copper, arsenic, zinc, cadmium, and lead in seawater and suspended particles in the South China Sea by collection of samples from different depths at sixteen stations. The salinity, temperature, pH, dissolved organic carbon, dissolved oxygen, and silicon concentration were also measured in seawater. The results showed that the concentration levels in seawater from 0 m to 4000 m followed this pattern: zinc > arsenic > copper > lead > chromium > cadmium. Significant correlations were observed between lead and chromium and between arsenic, cadmium, and lead at r > 0.728. Very weak correlations were observed between copper and arsenic and between copper and cadmium. The concentrations of dissolved metals and particulate metals had negative correlations except for zinc. The metal concentrations in seawater and suspended particles showed different correlation behavior with salinity, temperature, pH, dissolved oxygen, dissolved organic carbon, and silicon. 相似文献
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For reasonable assessment and safe exploitation of marine gas hydrate resource, it is important to determine the stability conditions of gas hydrates in marine sediment. In this paper, the seafloor water sample and sediment sample (saturated with pore water) from Shenhu Area of South China Sea were used to synthesize methane hydrates, and the stability conditions of methane hydrates were investigated by multi-step heating dissociation method. Preliminary experimental results show that the dissociation temperature of methane hydrate both in seafloor water and marine sediment, under any given pressure, is depressed by approximately -1.4 K relative to the pure water system. This phenomenon indicates that hydrate stability in marine sediment is mainly affected by pore water ions. 相似文献
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In recent years,oil spills caused by human activities have occurred frequently,and the resultant oil pollution has received extensive attention worldwide.In this paper,a total of 50 water samples were collected from the northeastern part of the South China Sea,and total petroleum hydrocarbons(TPHs)and n-alkane content in the samples were analyzed by gas chromatography-flame ionization detector(GC-FID) technology.The petroleum hydrocarbon characteristic indices,such as carbon predominance index(C... 相似文献
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Rapid access to the ABCE ring system of the C-20 diterpene alkaloids was achieved by silver (I) promoted intramolecular Friedel-Crafts arylation of a functional group specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative. 相似文献
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Naonobu Tanaka Rei Momose Azusa Takahashi-Nakaguchi Tohru Gonoi Jane Fromont Jun'ichi Kobayashi 《Tetrahedron》2014
Six new indole alkaloids, hyrtimomines F–K (1–6), were isolated from Okinawan marine sponges Hyrtios spp. The structures of 1–6 were elucidated on the basis of spectroscopic analysis. Hyrtimomine F (1) is a structurally unique bisindole alkaloid possessing an α-keto-?-caprolactam ring, while hyrtimomine G (2) is a symmetrical bisindole alkaloid. Hyrtimomines H–K (3–6) are indole alkaloids possessing β-carboline skeleton with an imidazolium unit. Antimicrobial activities of hyrtimomines F–K (1–6) were evaluated. 相似文献