| 三氯锗取代丙酰氢化噻唑-2-硫酮类化合物及其水解产物的合成 |
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| 引用本文： | 黄化民,李叶芝,郝素娥,王玉平. 三氯锗取代丙酰氢化噻唑-2-硫酮类化合物及其水解产物的合成[J]. 高等学校化学学报, 1990, 11(11): 1295 |
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| 作者姓名： | 黄化民 李叶芝 郝素娥 王玉平 |
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| 作者单位： | 吉林大学化学系, 130023 |
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| 摘 要： | 某些有机锗化物,例如β-羧乙基锗倍半氧化物及其衍生物能诱发干扰素,对癌症有一定疗效,日本专利报道丙酰胺基锗倍半氧化物及其衍生物也具有抗癌活性[2,3],白明章等曾合成丙酰芳胺基锗倍半氧化物[4]。
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| 关 键 词： | 三氯锗取代丙酰基四氢噻唑-2-硫酮 三氯锗取代丙酰基苯并二氢噻唑-2-硫酮 &beta -取代丙酰四氢噻唑-2-硫酮基锗倍半氧化物 &beta -取代丙酰苯并二氢噻唑-2-硫酮基锗倍半氧化物 |
| 收稿时间： | 1989-04-14 |
Synthesis of N-(Trichlorpgermyl) Substituted Propionyl Hydrothiazol-2-Thiones Compounds and Their Hydrolysis Products |
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| Huang Huamin,Li Yezhi,Hao Sue,Wang Yuping. Synthesis of N-(Trichlorpgermyl) Substituted Propionyl Hydrothiazol-2-Thiones Compounds and Their Hydrolysis Products[J]. Chemical Research In Chinese Universities, 1990, 11(11): 1295 |
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| Authors: | Huang Huamin Li Yezhi Hao Sue Wang Yuping |
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| Affiliation: | Department of Chemistry, Jilin University, Changchun, 130023 |
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| Abstract: | In this paper trichlorogermyl propionyl chlorides Ⅱa-c were prepared by the reaction of trichlorogermyl propionic acid Ⅰa-c with sulfenyl dichloride in 86%～9.1% yields.The compounds Ⅱa-c reacted with thiazolidine-2-thione or 2-mercaptobcnzothiazolc to form the N-(trichlorogermyl) substituted propionyl-thiazolidine-2-thione Ⅲu-c and N-(trichlorogermyl) substituted propionyl benzothiazoline-2-thione IVa-c in 62.9%～97.7% yields.The β-substituted propionyl thiazolidine-2-thionyl germanium sesquioxide Va-cand β-substituted propionyl benzothiazoline-2-thionyl germanium sesquioxide VIa-c were obtained by hydrolysis of compounds Ⅲa-c and Ⅲa-c in 44.0%～83.8% yields.The compounds Ⅱb-c, Ⅲa-c, Ⅳa-c, Ⅴa-c and VIa-c are new compounds. |
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| Keywords: | N-(Trichlorogermyl) substituted propionyl thiazolidine-2-thione N-(Trichlorogcrmyl) substituted propionyl benzothiazoline-2-thione β-Substitutcd propionyl thiazolidine-2-thionyl germanium sesquioxide β-substituted propionyl benzothiazoline |
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