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Synergistic Catalysis: Enantioselective Addition of Alkylbenzoxazoles to Enals |
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| Authors: | Marta Meazza Victor Ceban Dr. Mateusz B. Pitak Prof. Dr. Simon J. Coles Prof. Dr. Ramon Rios |
| Affiliation: | Faculty of Natural and Environmental Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ (UK) www.riosresearchgroup.com |
| Abstract: | A novel catalytic enantioselective methodology based on synergistic catalysis is reported. The strategy involves: 1) the metal‐Lewis‐acid activation of alkylazaarenes, and 2) the secondary‐amine activation of enals. Consequently, highly functionalized chiral alkylazaarenes were obtained in good yields and with reasonable stereoselectivity. |
| Keywords: | alkyl azaarenes iminium catalysis Michael addition palladium synergistic catalysis |