| O-(3-三苯锗基)正丙基硫代磷酸酯及类似物的合成 |
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| 引用本文： | 曾宪顺,曾强,崔涛,汪清民,李东波. O-(3-三苯锗基)正丙基硫代磷酸酯及类似物的合成[J]. 化学学报, 1999, 57(2): 196-201 |
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| 作者姓名： | 曾宪顺 曾强 崔涛 汪清民 李东波 |
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| 作者单位： | 南开大学元素有机化学研究所.天津(300071) |
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| 摘 要： | 首次采用3-三苯锗基正丙醇及其衍生物和硫代磷酸类的合成路线,合成了13个标题新化合物。其结构由IR,^1HNMR及MS等手段鉴定。研究结果表明:以NaH作缚酸剂,18-冠-6作相转移催化剂可以大大加速反应。体外实验表明,部分化合物对KB,A2780,HCT-8等癌细胞有较好的抑制活性。
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| 关 键 词： | 硫代磷酸酯 锗烷 生物活性 三苯锗基 |
| 修稿时间： | 1997-11-03 |
Synthesis of O-(3-triphenylgermyl) propyl phosphorothioates and their derivatives |
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| ZENG Xian-Shun,ZENG Qiang,Cui Tao,WANG Qing-min,LI Dong-bo. Synthesis of O-(3-triphenylgermyl) propyl phosphorothioates and their derivatives[J]. Acta Chimica Sinica, 1999, 57(2): 196-201 |
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| Authors: | ZENG Xian-Shun ZENG Qiang Cui Tao WANG Qing-min LI Dong-bo |
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| Affiliation: | Nankai Univ, Elementoorgan Chem Lab.Tianjin(300071) |
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| Abstract: | Thirteen titled compounds were synthesized by the reaction of O - alkyl - O - aryl phosphochloridothioates with 3 - (triphenylgermyl) - 1 - propanols. Their structures were confirmed by IR, 1H NMR, MS and elementary analyses. The reaction can be accelerated by addition of phase transfer catalysts and the best results were obtained in the presence of 18 - crown - 6. Some of these compounds showed antitumor activities in vitro . |
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| Keywords: | 3-(triphenylgermyl)-1-propanol phosphorothioates 3-triphenylgelmyl-1-phenyl-1-butanol synthesis bioactivity |
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