| 具有咖啡酰基和没食子酰基的β-二酮酸及喹噁啉酮类HIV整合酶抑制剂的设计合成及其对Cu2+的选择性识别 |
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| 引用本文： | 徐义生,曾程初,李雪梅,钟儒刚,曾毅. 具有咖啡酰基和没食子酰基的β-二酮酸及喹噁啉酮类HIV整合酶抑制剂的设计合成及其对Cu2+的选择性识别[J]. 中国化学, 2006, 24(8): 1086-1094. DOI: 10.1002/cjoc.200690203 |
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| 作者姓名： | 徐义生 曾程初 李雪梅 钟儒刚 曾毅 |
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| 作者单位： | College of Life Science ＆ Bio-Engineering, Beijing University of Technology, Beijing 100022, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China(No.20402001)，the Special Foundation for Beijing Municipal(No.2004D0501520)，Beijing Novel Project(No.2005B10). |
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| 摘 要： | An efficient procedure for the synthesis of caffeoyl-and galloyl-containing β-diketoacid derivatives linked byarylamide was reported by,in the key step,dissolving the corresponding phenyl methyl ketone in THF/DME in thepresence of NaOMe as base and dimethyl oxalate as oxalylation reagent,and then separating the sodium ketoe-nolate ester.The resulting β-diketoacids underwent further condensation reaction with o-phenylenediamine to gen-erate quinoxalone derivatives in good yield,rather than 2-benzimidazol.The preliminary ion binding properties ofquinoxalone derivatives were also investigated.UV-Vis spectra showed that these compounds could selectively rec-ognize Cu~(2 )ion in ethanol and form a 1∶2 complex.
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| 关 键 词： | 二酮酸 喹啉氧酮衍生物 HIV整合酶抑制剂 Cu^2＋识别 芳基氨 |
| 收稿时间： | 2005-11-02 |
| 修稿时间： | 2005-11-022006-04-05 |
Design,Synthesis and Cu2+ Recognition of β‐Diketoacid and Quinoxalone Derivatives Bearing Caffeoyl or Galloyl Moieties Linked by Arylamide as Potential HIV Integrase Inhibitors |
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| XU Yi-Sheng, ZENG Cheng-Chu, LI Xue-Mei, ZHONG Ru-Gang,ZENG Yi. Design,Synthesis and Cu2+ Recognition of β‐Diketoacid and Quinoxalone Derivatives Bearing Caffeoyl or Galloyl Moieties Linked by Arylamide as Potential HIV Integrase Inhibitors[J]. Chinese Journal of Chemistry, 2006, 24(8): 1086-1094. DOI: 10.1002/cjoc.200690203 |
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| Authors: | XU Yi-Sheng ZENG Cheng-Chu LI Xue-Mei ZHONG Ru-Gang ZENG Yi |
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| Abstract: | An efficient procedure for the synthesis of caffeoyl‐ and galloyl‐containing β‐diketoacid derivatives linked by arylamide was reported by, in the key step, dissolving the corresponding phenyl methyl ketone in THF/DME in the presence of NaOMe as base and dimethyl oxalate as oxalylation reagent, and then separating the sodium ketoenolate ester. The resulting β‐diketoacids underwent further condensation reaction with o‐phenylenediamine to generate quinoxalone derivatives in good yield, rather than 2‐benzimidazol. The preliminary ion binding properties of quinoxalone derivatives were also investigated. UV‐Vis spectra showed that these compounds could selectively recognize Cu2+ ion in ethanol and form a 1:2 complex. |
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| Keywords: | diketoacid quinoxalone derivative HIV integrase inhibitor Cu~(2 ) recognition |
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