|
|||||
|
|
| 血管硒蛋白与动脉粥样硬化 | |
| 引用本文： | 黄开勋,刘红梅,徐辉碧. 血管硒蛋白与动脉粥样硬化[J]. 化学进展, 2009, 21(5): 831-835 |
| 作者姓名： | 黄开勋 刘红梅 徐辉碧 |
| 作者单位： | 华中科技大学化学与化工学院,生物无机化学与药物湖北省重点实验室,武汉,430074;华中科技大学化学与化工学院,生物无机化学与药物湖北省重点实验室,武汉,430074;华中科技大学化学与化工学院,生物无机化学与药物湖北省重点实验室,武汉,430074 |
| 基金项目： | 国家自然科学基金项目(No.20671037,30870555)资助 |
| 摘 要： | 动脉粥样硬化是一种严重危害人类健康的慢性炎症血管疾病，随着我国人民生活水平的不断提高和人口的老龄化，其发病率逐年增高。本文结合本课题组的工作，对血管硒蛋白与动脉粥样硬化的关系进行了介绍。主要的研究进展表明：动脉粥样硬化的发生与血管氧化性损伤有密切关系，硒作为一种重要的必需微量元素主要以硒蛋白的形式存在于血管之中，对氧化型固醇导致的血管损伤有明显的抑制作用；其机理可能与硒蛋白的抗氧化作用、调节血液前列环素和血栓素的比例改善血液流通、以及抑制氧化型固醇诱导的血管细胞凋亡等有关。 |
| 关 键 词： | 硒血管硒蛋白 动脉粥样硬化 氧化损伤 |
| 收稿时间： | 2009-01-14 |
| 修稿时间： | 2009-01-27 |
Vascular Selenoproteins and Atherosclerosis |
|
| Huang Kaixun Liu Hongmei Xu Huibi. Vascular Selenoproteins and Atherosclerosis[J]. Progress in Chemistry, 2009, 21(5): 831-835 | |
| Authors: | Huang Kaixun Liu Hongmei Xu Huibi |
| Affiliation: | (Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China) |
| Abstract: | Atherosclerosis, a chronic inflammatory disease of the arterial wall, exerts serious influence to human health. Along with the rising living standard and aging of the population, the morbidity of atherosclerosis increases year by year. This review discusses the relationship between vascular selenoprotein and atherosclerosis in corporation with authors′ work. Recent progresses show that the occurrence and development of atherosclerosis are closely related to oxidative damage of blood vessels, and selenium, as an essential trace element for humans, exerts its biological effect through selenoproteins and plays an important role in the inhibition of vascular oxidative damage and the prevention of atherosclerosis induced by oxysterols. The mechanism may be related to (i) effect on antioxidant capacity of arterial wall, (ii) regulation of oxysterols-induced abnormal ratio of prostacyclin and thromboxane, (iii) inhibiting effect on oxysterols-induced apoptosis of vascular smooth muscle cells.Contents 1 Oxysterol and atherosclerosis 2 Selenium in vascular wall 3 Inhibition of selenium on atherosclerosis 4 Mmechanism of selenium inhibiting atherosclerosis 4.1 Effect of selenium on antioxidant capacity of arterial wall 4.2 Regulation of selenium on oxysterols-induced abnormality of prostacyclin and thromboxane 4.3 Inhibiting effect of selenium on oxysterols-induced apoptosis of vascular smooth muscle cells 5 Prospects |
| Keywords: | selenium selenoprotein atherosclerosis oxidative damage |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《化学进展》浏览原始摘要信息 | |
| 点击此处可从《化学进展》下载全文 | |