Intramolecular Fluorocyclizations of Unsaturated Carboxylic Acids with a Stable Hypervalent Fluoroiodane Reagent |
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| Authors: | Gemma C. Geary Prof. Eric G. Hope Dr. Alison M. Stuart |
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| Affiliation: | Department of Chemistry, University of Leicester, Leicester, LE1 7RH (UK) |
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| Abstract: | A new class of fluorinated lactones was prepared by the intramolecular fluorocyclizations of unsaturated carboxylic acids by using the stable fluoroiodane reagent in combination with AgBF4. This unique reaction incorporates a cyclization, an aryl migration, and a fluorination all in one step. The fluoroiodane reagent, prepared easily from fluoride, can also be used without a metal catalyst to give moderate yields within just 1 hour, thus demonstrating that it is a suitable reagent for developing new 18F‐labelled radiotracers for PET imaging. |
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| Keywords: | cyclizations fluorine hypervalent compounds lactones silver |
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