Chiral Sulfinamide Bisphosphine Catalysts: Design,Synthesis, and Application in Highly Enantioselective Intermolecular Cross‐Rauhut–Currier Reactions |
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| Authors: | Wei Zhou Xiao Su Mengna Tao Chaoze Zhu Dr. Qingjie Zhao Prof. Dr. Junliang Zhang |
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| Affiliation: | 1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 (P. R. China) http://faculty.ecnu.edu.cn/s/1811/main.jspy;2. Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433 (P. R. China) |
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| Abstract: | A novel type of highly efficient chiral sulfinamide bisphosphine catalysts (Wei‐Phos) were developed. These could be easily prepared from commercially available starting materials. Wei‐Phos has shown good performance in the very challenging intermolecular cross‐Rauhut–Currier reactions of vinyl ketones and 3‐acyl acrylates or 2‐ene‐1,4‐diones, leading to the R‐C products in high yields with up to 99 % ee under 2.5–5 mol% catalyst loading. The highly regio‐ and enantio‐selective cross‐Rauhut–Currier reactions of 2‐ene‐1,4‐diones and vinyl ketone have yet reported so far. |
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| Keywords: | alkenes asymmetric catalysis chiral sulfinamidephosphines organocatalysis Rauhut– Currier reaction |
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