Iron‐catalyzed cross‐coupling of heteroaromatic tosylates with alkyl and aryl Grignard reagents |
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| Authors: | Xu Chen Zheng‐Jun Quan Xi‐Cun Wang |
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| Affiliation: | 1. Key Laboratory of Eco‐Environment‐Related Polymer Materials, Ministry of Education of China, Gansu, People's Republic of China;2. Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Gansu, People's Republic of China |
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| Abstract: | An Fe(III)‐catalyzed cross‐coupling of N‐heteroaromatic tosylates with aryl and alkyl Grignard reagents is presented. The reaction proceeds at ?20°C to room temperature with short reaction time (15–30 min.), and the corresponding products are obtained with moderate to high yields. In particular, low‐cost and abundantly available FeCl3 or Fe(acetylacetonate)3 catalyze the reaction without other special ligands. All tested N‐heteroaromatic tosylates that are available including pyridine and pyrimidine derivatives were subject to the reaction, resulting in the expected products. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | cross‐coupling heteroaromatic sulfonates Grignard reagents pyrimidine derivatives |
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