Synchronized Anti-Phase and In-Phase Oscillations of Intracellular Calcium Ions in Two Coupled Hepatocytes System |
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| Authors: | SHEN Chuan-Sheng CHEN Han-Shuang ZHANG Ji-Qian |
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| Affiliation: | Department of Educational Technology, Anqing Teachers College, Anqing 246011College of Physics and Electronic Information, Anhui Normal University, Wuhu 241000 |
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| Abstract: | We study the dynamic behaviour of two intracellular calcium oscillators that are coupled through gap junctions both to Ca2+ and inositol(1,4,5)-trisphosphate (IP3). It is found that synchronized anti-phase and in-phaseoscillations of cytoplasmic calcium coexist in parameters space. Especially, synchronized anti-phase oscillations only occur near the onset of a Hopf bifurcation point when the velocity of IP3 synthesis is increased. In addition, two kinds of coupling effects, i.e., the diffusions of Ca2+ and IP3 among cells on synchronous behaviour, are considered. We find that small coupling ofCa2+ and large coupling of IP3 facilitate the emergence of synchronized anti-phase oscillations. However, the result is contrary for the synchronized in-phase case. Our findings may provide a qualitative understanding about the mechanism of synchronous behaviour of intercellular calcium signalling. |
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| Keywords: | 05.45.Xt 05.45.-a 05.40.-a |
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