Dual Ligand‐Enabled Nondirected C−H Olefination of Arenes |
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| Authors: | Hao Chen Philipp Wedi Tim Meyer Dr. Ghazal Tavakoli Dr. Manuel van Gemmeren |
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| Affiliation: | 1. Max Planck Institute for Chemical Energy Conversion, Mülheim an der Ruhr, Germany;2. Organisch-Chemisches Institut, Westf?lische Wilhelms-Universit?t Münster, Münster, Germany |
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| Abstract: | The application of the Pd‐catalyzed oxidative C?H olefination of arenes, also known as the Fujiwara–Moritani reaction, has traditionally been limited by the requirement for directing groups on the substrate or the need to use the arene in large excess, typically as a (co)solvent. Herein the development of a catalytic system is described that, through the combined action of two complementary ligands, makes it possible to use directing‐group‐free arenes as limiting reagents for the first time. The reactions proceed under a combination of both steric and electronic control and enable the application of this powerful reaction to valuable arenes, which cannot be utilized in excess. |
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| Keywords: | arenes C− H activation Fujiwara– Moritani reaction olefination palladium |
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