|
|||||
|
|
Radical CH Functionalization of Heteroarenes under Electrochemical Control |
|
| Authors: | Dr. Alexander G. O'Brien Dr. Akinobu Maruyama Dr. Yasuhide Inokuma Prof. Makoto Fujita Prof. Phil S. Baran Prof. Donna G. Blackmond |
| Affiliation: | 1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA);2. Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo‐ku, Tokyo, 113‐8656 (Japan) |
| Abstract: | Electrochemical reactions are shown to be effective for the C? H functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the C? H functionalization of a series of heterocycles of interest in medicinal chemistry. |
| Keywords: | C H activation electrochemistry heterocycles radical reactions reaction mechanisms |