Enantioselective CH Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene |
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| Authors: | Peng Yu Jin‐Shun Lin Lei Li Sheng‐Cai Zheng Ya‐Ping Xiong Li‐Jiao Zhao Prof. Dr. Bin Tan Prof. Dr. Xin‐Yuan Liu |
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| Affiliation: | Department of Chemistry, South University of Science and Technology of China, Shenzhen, 518055 (P. R. China) |
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| Abstract: | An asymmetric unactivated alkene/C? H bond difunctionalization reaction for the concomitant construction of C? CF3 and C? O bonds was realized by using a Cu/Brønsted acid cooperative catalytic system, thus providing facile access to valuable chiral CF3‐containing N,O‐aminals with excellent regio‐, chemo‐, and enantioselectivity. Mechanistic studies revealed that this reaction may proceed by an unprecedented 1,5‐hydride shift involving activation of unactivated alkenes and a radical trifluoromethylation to initiate subsequent enantioselective functionalization of C? H bonds. Control experiments also suggested that chiral Brønsted acid plays multiple roles and not only controls the stereoselectivity but also increases the reaction rate through activation of Togni’s reagent. |
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| Keywords: | C H activation copper enantioselectivity radical chemistry reaction mechanisms |
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