Diastereoselective Synthesis of Vicinally Bis(trifluoromethylated) Alkylboron Compounds through Successive Insertions of 2,2,2‐Trifluorodiazoethane |
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| Authors: | Prof. Gary A. Molander DaWeon Ryu |
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| Affiliation: | Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104‐6323 (USA) |
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| Abstract: | The usefulness of embedded CF3 substituents within organic substructures necessitates the development of diverse methods for incorporating this functional group. A recently reported route to α‐trifluoromethylated alkylboron compounds by an α‐transfer mechanism has now been extended to the synthesis of unprecedented, vicinally ditrifluoromethylated alkylboron compounds in a diastereoselective fashion. The utility of these products is highlighted by conversion of the C? B bond into other functional groups. |
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| Keywords: | boron diastereoselectivity diazo compounds synthetic methods trifluoromethylation |
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