| 苦参碱和槐定碱在多刺激响应性水凝胶薄膜电极上的可调控电化学行为及其逻辑门构建 |
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| 引用本文： | 吴雪梅,韦洁,许红平,左玲霞,单晓艳,姚惠琴,郑志祥. 苦参碱和槐定碱在多刺激响应性水凝胶薄膜电极上的可调控电化学行为及其逻辑门构建[J]. 高等学校化学学报, 2019, 40(4): 685. DOI: 10.7503/cjcu20180741 |
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| 作者姓名： | 吴雪梅 韦洁 许红平 左玲霞 单晓艳 姚惠琴 郑志祥 |
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| 作者单位： | 宁夏医科大学药学院,银川,750004;宁夏医科大学基础医学院,银川,750004;宁夏医科大学药学院, 银川 750004;宁夏医科大学基础医学院, 银川 750004;甘肃政法学院,甘肃省证据科学技术研究与应用重点实验室, 兰州 730070 |
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| 基金项目： | 宁夏自然科学基金(批准号: NZ17052)、 大学生创新实验项目(批准号: NXCX2016139)、 国家自然科学基金(批准号: 21665021)和西部一流基础医学学科项目资助. |
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| 摘 要： | 采用苦参碱(Matrine, MT)和槐定碱(Sophoridine, SR)作为电活性药物分子探针, 考察了聚(N-异丙基)丙烯酰胺(PNIPAM)水凝胶薄膜的刺激响应特性; 并通过循环伏安(CV)法和扫描电子显微镜(SEM)研究了PNIPAM在不同外界刺激条件(如温度、 盐浓度和甲醇)下结构的改变. 在25 ℃时, 药物分子MT和SR在玻碳电极上产生较大的氧化峰电流, 随着温度升高至40 ℃, 药物分子探针的氧化峰电流逐渐减小. 考察了不同Na2SO4浓度和不同比例甲醇对PNIPAM水凝胶薄膜的影响, 发现MT和SR的氧化峰电流随着Na2SO4浓度(00.45 mol/L)和甲醇比例(040%)的升高而减小. 结果表明, MT和SR可作为分子探针研究PNIPAM水凝胶薄膜对环境的三重刺激响应性开关行为, 并可进一步构筑3-输入/2-输出的逻辑门系统.
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| 关 键 词： | 苦参碱 槐定碱 聚(N-异丙基)丙烯酰胺 可调控 逻辑门 |
| 收稿时间： | 2018-11-01 |
Switchable Electrochemical Behavior of Matrine and Sophoridine at Multi-stimuli Responsive Hydrogel Film Electrode and Construction of Logic Gate† |
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| WU Xuemei,WEI Jie,XU Hongping,ZUO Lingxia,SHAN Xiaoyan,YAO Huiqin,ZHENG Zhixiang. Switchable Electrochemical Behavior of Matrine and Sophoridine at Multi-stimuli Responsive Hydrogel Film Electrode and Construction of Logic Gate†[J]. Chemical Research In Chinese Universities, 2019, 40(4): 685. DOI: 10.7503/cjcu20180741 |
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| Authors: | WU Xuemei WEI Jie XU Hongping ZUO Lingxia SHAN Xiaoyan YAO Huiqin ZHENG Zhixiang |
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| Affiliation: | 1. College of Pharmacy, 2. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China2. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China3. Key Laboratory of Evidence Science Technology Research and Application, Gansu Institute of Political Science and Law, Lanzhou 730070, China |
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| Abstract: | Matrine(MT) and sophoridine(SR) were used as electroactive drug molecular probes to investigate the stimuli-responsive characteristics of the hydrogels poly(N-isopropyl)acrylamide(PNIPAM), and the changes of PNIPAM structure under different external stimuli(temperature, salt concentration and methanol) were observed by cyclic voltammetry(CV) method and scanning electron microscopy(SEM). The results show that at 25 ℃, MT and SR lead to a large oxidation peak current; when the temperature reached at 40 ℃, the oxidation peak currents of MT and SR are gradually reduced. The influence of different Na2SO4 concentration and different proportion of methanol on PNIPAM hydrogel were also investigated. The oxidation peak currents of MT and SR decreased with the increasing of Na2SO4 concentration(0—0.45 mol/L) and volume fraction of methanol ratio(0—40%). The results indicate that MT and SR could be used as molecular probes to investigate the switching behaviors of PNIPAM hydrogel films, and further constructed 3-input/2-output logic gate system. |
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| Keywords: | Matrine Sophoridine Poly(N-isopropyl)acrylamide Controllable Logic gate |
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