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N‐Heterocyclic Carbene‐Catalyzed Enantioselective Annulation of Indolin‐3‐ones with Bromoenals |
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| Authors: | Qijian Ni Xiaoxiao Song Prof. Dr. Gerhard Raabe Prof. Dr. Dieter Enders |
| Affiliation: | Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany), Fax: (+49)?0241‐80‐92127 |
| Abstract: | N‐Heterocyclic carbene‐catalyzed reactions of indolin‐3‐ones with 2‐bromoenals opened an asymmetric access to 3,4‐dihydropyrano[3,2‐b]indol‐2(5 H)‐ones in good yields and with good to excellent enantioselectivities. This protocol tolerates a broad substrate scope. In addition, a possible mechanism for the annulation reaction is presented. |
| Keywords: | annulation asymmetric synthesis dihydropyranoindol‐2‐ones N‐heterocyclic carbenes organocatalysis |