| Research Progress of Regulation of Driving Forces in Short Peptide Supramolecular Self-Assembly北大核心CSCD |
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| 作者姓名： | 张伟强 王晨 赵玉荣 王栋 王继乾 徐海 |
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| 作者单位： | 中国石油大学（华东）化学工程学院生物工程与技术中心，青岛 266580 |
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| 基金项目： | 国家自然科学基金项目(Nos.22072181,U1832108)资助~~； |
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| 摘 要： | Some short peptides can spontaneously self-assemble into various nanostructures via the synergistic driving forces of non-covalent interactions. These non-covalent interactions，including electrostatic interaction，hydrogen bonding，aromatic interactions and other non-covalent interactions，are usually highly coupled together. Through rational sequence design and proper modification of short peptide molecules，the driving forces could be regulated purposively，and the nanostructures and morphologies of the self-assemblies could be controlled accordingly，and thus so as to achieve the fabrication of peptide-based supramolecular biomaterials and develop their functions. In this paper，the effects of hydrogen bonding，π-π stacking， electrostatic interaction，hydrophobic interaction，metal ion coordination and chiral center on the self-assembly behavior of peptide self-assembly have been reviewed. The driving force regulation strategies， including sequence design，pH and concentration adjustment and metal ion coordination，and the resulted nanostructures have also been discussed. We also make the outlooks on the development of peptide-based supramolecular biomaterials with specific functions in biomedicines and biocatalysis. © 2022, Science Press (China). All rights reserved.
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| 关 键 词： | Chirality Coordination Electrostatic interaction Hydrogen bond Hydrophobic interaction Peptide self-assembly π-π stacking |
| 收稿时间： | 2021-10-24 |
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