Silver‐Promoted Oxidative Benzylic C−H Trifluoromethoxylation |
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| Authors: | Haodong Yang Feng Wang Xiaohuan Jiang Yu Zhou Prof. Xiufang Xu Prof. Pingping Tang |
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| Affiliation: | 1. State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China;2. Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin, China |
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| Abstract: | A silver‐promoted oxidative benzylic C?H trifluoromethoxylation has been reported for the first time. With trifluoromethyl arylsulfonate as the trifluoromethoxylation reagent, various arenes, having diverse functional groups, undergo trifluoromethoxylation of their benzylic C?H bonds to form trifluoromethyl ethers under mild reaction conditions. In addition, the trifluoromethoxylation and the fluorination of methyl groups of electron‐rich arenes have been achieved to prepare α‐fluorobenzyl trifluoromethyl ethers in one step. |
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| Keywords: | C− H functionalization fluorine reaction mechanisms silver synthetic methods |
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