| 非糖尿病绝经后女性胰岛素抵抗与骨代谢的相关性研究 |
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| 引用本文： | 林伊荷,刘芳,牛亚丹,李冬梅,李宇宁,徐冉行,陈青山,徐雷艇. 非糖尿病绝经后女性胰岛素抵抗与骨代谢的相关性研究[J]. 宁波大学学报(理工版), 2022, 0(3): 63-69 |
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| 作者姓名： | 林伊荷 刘芳 牛亚丹 李冬梅 李宇宁 徐冉行 陈青山 徐雷艇 |
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| 作者单位： | 1.宁波大学 医学院, 浙江 宁波 315211; 2.宁波市鄞州区明楼街道社区卫生服务中心, 浙江 宁波 315040; 3.宁波市第六医院, 浙江 宁波 315040; 4.宁波市鄞州区东柳街道社区卫生服务中心, 浙江 宁波 315040 |
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| 基金项目： | 浙江省自然科学基金（LY16H070001）； |
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| 摘 要： | 为探讨胰岛素抵抗与骨代谢之间的相互关系,采用双能X线吸收仪测量了262名非糖尿病绝经后女性腰椎L1-4和股骨颈(Femoral Neck,FN)的骨密度(Bone Mineral Density,BMD),并检测了其外周血骨转换标志物和糖代谢指标以及雌激素水平.结果发现胰岛素和稳态模型评估的胰岛素抵抗(Homeosta...
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| 关 键 词： | 胰岛素抵抗 骨质疏松症 骨密度 骨转换标志物 |
Association between insulin resistance and bone metabolism in non-diabetic postmenopausal women |
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| LIN Yihe1,LIU Fang1,NIU Yadan1,LI Dongmei2,LI Yuning3,XU Ranxing3,CHEN Qingshan4,XU Leiting1. Association between insulin resistance and bone metabolism in non-diabetic postmenopausal women[J]. Journal of Ningbo University(Natural Science and Engineering Edition), 2022, 0(3): 63-69 |
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| Authors: | LIN Yihe1 LIU Fang1 NIU Yadan1 LI Dongmei2 LI Yuning3 XU Ranxing3 CHEN Qingshan4 XU Leiting1 |
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| Affiliation: | 1.School of Medicine, Ningbo University, Ningbo 315211, China; 2.Minglou Community Health Service Center, Ningbo 315040, China; 3.Ningbo No.6 Hospital, Ningbo 315040, China; 4.Dongliu Community Health Service Center, Ningbo 315040, China |
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| Abstract: | The current study was aimed to investigate the relationship between insulin (INS) resistance and bone metabolism, the bone mineral density (BMD) of lumbar spine L1-4 and femoral neck (FN) in 262 non-diabetic postmenopausal women who were diagnosed by dual-energy X-ray absorptiometry. Bone turnover markers, glucose metabolism and estrogen levels in peripheral blood were measured. The results showed that INS and homeostasis model assessment of insulin resistance (HOMA-IR) index were positively correlated with L1-4 and FN BMD (P<0.01). However, the correlation did not hold after controlling body mass index (BMI) and free estradiol (FE2) levels (P>0.05). OP risk in the high HOMA-IR group (OR=0.59, P=0.003) and middle HOMA- IR group (OR=0.52, P=0.044) was significantly lower than that in the low HOMA-IR group. However, the difference was no longer existing after adjusting for BMI and FE2 (OR=0.81, P=0.263 and OR=0.68, P=0.268, respectively). The osteocalcin (OCN) level in the high HOMA-IR group was significantly lower than that in the low HOMA-IR group (P=0.001) and the difference was still statistically significant even after adjusting for BMI and FE2 (P=0.027). Therefore, INS resistance was not an independent protective or risk factor for OP in non-diabetic postmenopausal women. OCN may be involved in glucose metabolism by influencing peripheral tissue INS sensitivity. |
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| Keywords: | insulin resistance osteoporosis bone mineral density bone turnover markers |
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