Direct Trifluoromethylthiolation of Alcohols under Mild Reaction Conditions: Conversion of ROH into RSCF3 |
| |
| Authors: | Pavlo Nikolaienko Roman Pluta Prof. Dr. Magnus Rueping |
| |
| Affiliation: | Institute of Organic Chemistry, Institution RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany) |
| |
| Abstract: | A direct process for the trifluoromethylthiolation of allylic and benzylic alcohols under mild conditions has been developed. A wide range of free alcohols underwent nucleophilic substitution in the presence of stable CuSCF3 and BF3 ? Et2O to give the corresponding products in good to excellent yields. |
| |
| Keywords: | alcohols nucleophilic substitution thioethers trifluoromethyl sulfenylation |
|
