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Silica‐Encapsulated Gd3+‐Aggregated Gold Nanoclusters for In Vitro and In Vivo Multimodal Cancer Imaging |
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| Authors: | Xiaotong Wu Dr. Chunxia Li Suchan Liao Dr. Lu Li Dr. Tingting Wang Prof. Zhongmin Su Prof. Chungang Wang Jihong Zhao Changping Sui Prof. Jun Lin |
| Affiliation: | 1. Faculty of Chemistry, Northeast Normal University, Changchun, 130024 (P.R. China);2. Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (P.R. China);3. Basic Medical College of Bethune, Jilin University, Changchun, 130021 (P.R. China);4. School of Chemistry & Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022 (P.R. China);5. The Tumor Hospital of Jilin Province, Changchun, 130012 (P.R. China) |
| Abstract: | Gd3+‐aggregated gold nanoclusters (AuNCs) encapsulated by silica shell (Gd3+‐A‐AuNCs@SiO2 NPs) were strategically designed and prepared. The as‐prepared nanoparticles exhibit aggregation‐enhanced fluorescence (AEF), with an intensity that is up to 3.8 times that of discrete AuNCs. The clusters served as novel nanoprobes for in vitro and in vivo multimodal (fluorescence, magnetic resonance, and computed X‐ray tomography) cancer imaging |
| Keywords: | aggregation‐enhanced fluorescence cancer gold nanoclusters multimodal imaging |