Deoxyribonucleoside‐Modified Squaraines as Near‐IR Viscosity Sensors |
| |
| Authors: | Yuanwei Zhang Xiling Yue Bosung Kim Dr. Sheng Yao Prof. Dr. Kevin D. Belfield |
| |
| Affiliation: | 1. Department of Chemistry, University of Central Florida, P.O. Box 162366, Orlando, Florida 32816‐2366 (USA);2. CREOL, The College of Optics and Photonics, University of Central Florida (USA) |
| |
| Abstract: | Deoxyribonucleoside‐modified squaraines were synthesized by Sonogashira coupling reactions using an unsymmetrical, terminal alkynylated benzothiazolium squaraine dye. These non‐natural nucleosides exhibited fluorescent ‘turn‐on’ properties in viscous conditions with an enhancement of >300‐fold. The viscosity‐dependent fluorescence enhancement was attributed to a combination of hampering both molecular aggregation and intramolecular bond rotation of the squaraine probe. Fluorescence microscopy allowed visualization of highly viscous regions during various stages of cellular mitosis. |
| |
| Keywords: | aggregation deoxyribonucleosides near‐IR imaging squaraine dyes viscosity sensors |
|
