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Triazole‐Tailored Guanosine Dinucleosides as Biomimetic Ion Channels to Modulate Transmembrane Potential |
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| Authors: | Y. Pavan Kumar Rabindra Nath Das Sonu Kumar Ole Mathis Schütte Prof. Dr. Claudia Steinem Prof. Dr. Jyotirmayee Dash |
| Affiliation: | 1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata‐700 032 (India);2. Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur, ‐ 741 252 (India);3. Institute for Organic and Biomolecular Chemistry, Georg August University G?ttingen, Tammannstr. 2, 37077 G?ttingen (Germany) |
| Abstract: | A “click” ion channel platform has been established by employing a clickable guanosine azide or alkyne with covalent spacers. The resulting guanosine derivatives modulated the traffic of ions across the phospholipid bilayer, exhibiting a variation in conductance spanning three orders of magnitude (pS to nS). Förster resonance energy transfer studies of the dansyl fluorophore with the membrane binding fluorophore Nile red revealed that the dansyl fluorophore is deeply embedded in the phospholipid bilayer. Complementary cytosine can inhibit the conductance of the supramolecular guanosine channels in the phospholipid bilayers. |
| Keywords: | amphiphilic guanosine click chemistry ion channels inhibition phospholipid bilayers |