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Dynamic Self‐Assembly of Polycationic Clusters Based on Cyclodextrins for pH‐Sensitive DNA Nanocondensation and Delivery by Component Design |
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| Authors: | Laura Gallego‐Yerga Dr. M. José González‐Álvarez Natalia Mayordomo Prof. Francisco Santoyo‐González Dr. Juan M. Benito Prof. Carmen Ortiz Mellet Prof. Francisco Mendicuti Prof. José M. García Fernández |
| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, c/Profesor García González 1, 41011 Sevilla (Spain), Fax: (+34)?954624960;2. Department of Physical Chemistry, Faculty of Chemistry, Universidad de Alcalá, Edificio de Farmacia, Campus Universitario Ctra, Madrid‐Barcelona Km 33.600, 28871 Alcalá de Henares, Madrid (Spain), Fax: (+34)?918854763;3. Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, 18071 Granada (Spain);4. Instituto de Investigaciones Químicas (IIQ), CSIC—University of Sevilla, Avda. Americo Vespucio 49, 41092 Sevilla (Spain), Fax: (+34)?954460165 |
| Abstract: | The ability of cyclodextrin‐based polycationic cluster to undergo reversible DNA condensation and release in a physiologically useful pH window has been finely tuned by the installation of a capping xylylene moiety at the secondary face of the cyclooligosaccharide. This strategy can be exploited advantageously in the design of self‐assembling nonviral gene‐delivery systems from molecular entities. |
| Keywords: | cyclodextrin fluorescence gene delivery pH sensitivity self‐assembly |