General Catalytic Methylation of Amines with Formic Acid under Mild Reaction Conditions |
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| Authors: | Dr. Iván Sorribes Dr. Kathrin Junge Prof. Dr. Matthias Beller |
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| Affiliation: | Leibniz‐Institut für Katalyse e. V. an der Universit?t Rostock, Albert Einstein Str. 29a, 18059 Rostock (Germany), Fax: (+49)?381‐1281‐5000 |
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| Abstract: | A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [N‐13C]‐labelled drugs in good to excellent yields under mild conditions. |
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| Keywords: | formic acid homogeneous catalysis methylation platinum silanes |
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