| 电化学发光生物传感技术在快速检测心肌梗死标志物中的研究进展 |
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| 引用本文： | 覃晓丽,王茗涵,董逸帆,邵元华. 电化学发光生物传感技术在快速检测心肌梗死标志物中的研究进展[J]. 应用化学, 2018, 35(9): 1107-1112. DOI: 10.11944/j.issn.1000-0518.2018.09.180170 |
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| 作者姓名： | 覃晓丽 王茗涵 董逸帆 邵元华 |
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| 作者单位： | 北京大学化学与分子工程学院 分析化学研究所,北京分子科学国家研究中心 北京 100871 |
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| 基金项目： | 国家重点研发计划(2016YFA0201300)、国家自然科学基金(21335001,21575006)和中国博士后科学基金(2016M600846)项目资助 |
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| 摘 要： | 设计和发展简便、高灵敏、高选择性的分析手段以检测低浓度急性心肌梗死生物标志物是目前临床诊断迫切的需求。 电化学发光分析法由于具有稳定性好、灵敏度高、线性范围宽及可控性强等优点,能有效地进行低浓度样品检测。 该方法与生物传感技术相结合,有利于实现生物体液等复杂样品中极低含量急性心肌梗死生物标志物的快速检测。 本文综述了电化学发光生物传感技术在快速检测心肌梗死标志物中近5年的进展,介绍了电化学发光探针和共反应物,以及多组分生物传感检测技术等,并对其在心肌梗死标志物分析中的应用进行了总结。
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| 关 键 词： | 电化学发光 生物传感器 电化学发光探针 阵列 急性心肌梗死生物标志物分析 |
| 收稿时间： | 2018-05-14 |
Electrochemiluminescent Biosensing and Its Application in Rapid Detection of Acute Myocardial Infarction Markers |
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| QIN Xiaoli,WANG Minghan,DONG Yifan,SHAO Yuanhua. Electrochemiluminescent Biosensing and Its Application in Rapid Detection of Acute Myocardial Infarction Markers[J]. Chinese Journal of Applied Chemistry, 2018, 35(9): 1107-1112. DOI: 10.11944/j.issn.1000-0518.2018.09.180170 |
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| Authors: | QIN Xiaoli WANG Minghan DONG Yifan SHAO Yuanhua |
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| Affiliation: | Institute of Analytical Chemistry at College of Chemistry and Molecular Engineering,Beijing National Research Center for Molecular Sciences,Peking University,Beijing 100871,China |
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| Abstract: | Design and development of simple, ultrasensitive, and high selective analytical techniques and methods for the clinical diagnosis and monitoring of a series of acute myocardial infarction(AMI) markers are urgently required for complicated sample matrix. Due to its good stability, high sensitivity, wide linear range, and good controllability, electrochemiluminescent(ECL) analysis technique is commonly used for low-level analytes. Combined with biosensing, it shows great promise in assaying low-level AMI biomarkers in complicated matrix such as biological fluids. This review presents the development of ECL sensing technique for AMI bioanalysis in recent five years. Some ECL probes, co-reactants, multianalyte biosensing methods and their application in AMI marker analysis have been introduced. |
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| Keywords: | electrochemiluminescence biosensor electrochemiluminescence probes array acute myocardial infarction markers analysis |
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