Copper‐Catalyzed Aerobic Decarboxylation/Ketooxygenation of Electron‐Deficient Alkenes |
| |
| Authors: | Yi Luo Ying Zhao Minxian Zhou Prof. Aiwen Lei |
| |
| Affiliation: | 1. College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei (P. R. China);2. National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, Jiangxi (P. R. China) |
| |
| Abstract: | A copper‐catalyzed ketooxygenation of electron‐deficient alkenes was developed. This approach combines O?H alkylation, aerobic decarboxylation, and oxygenation in one transformation. Mechanistic investigation of this reaction showed that the copper salt is responsible for both generating the amidoxyl radical and promoting aerobic decarboxylation. |
| |
| Keywords: | copper catalysis decarboxylation dioxygen activation oxidative coupling radical coupling |
|
|
