An Efficient Synthesis of Benzazocines by Gold(I)‐Catalyzed Tandem 1,2‐Acyloxy Shift/[3+2] Cycloaddition of Terminal 1,9‐Enynyl Esters |
| |
| Authors: | Shangbiao Feng Zhengshen Wang Weiwei Zhang Prof. Dr. Xingang Xie Prof. Dr. Xuegong She |
| |
| Affiliation: | 1. State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, P. R. China;2. (+86)?931‐8912582;3. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China |
| |
| Abstract: | An effective synthesis of structurally diverse benzazocines was accomplished in good to excellent chemical yields (55–82 %) through a gold(I)‐catalyzed cascade reaction involving tandem 1,2‐acyloxy shift/[3+2] cycloaddition of terminal 1,9‐enynyl esters. The reaction proceeds under extremely mild conditions and represents one of the relatively few transition‐metal‐catalyzed intramolecular cycloaddition reactions for the synthesis of benzazocines. |
| |
| Keywords: | cycloaddition fused-ring systems gold homogeneous catalysis nitrogen heterocycles |
|
|
