A Simple and Efficient One‐pot Synthesis of 1,4‐dihydropyridines Using Nano‐WO3‐ supported Sulfonic Acid as an Heterogeneous Catalyst under Solvent‐free Conditions |
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| Authors: | Mehrnoosh Bitaraf Ali Amoozadeh Somayeh Otokesh |
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| Affiliation: | Faculty of Chemistry, Semnan University, Semnan 35131‐19111, Iran |
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| Abstract: | Nano‐tungsten trioxide‐supported sulfonic acid (n‐WSA) was found to be an effective heterogeneous cat‐ alyst for the one‐pot reaction of aromatic aldehydes, β‐dicarbonyl compounds and ammonium acetate to afford 1,4‐dihydropyridine derivatives in good to excellent yields. The other main advantages of the pres‐ ent method are short reaction times, simple workup, ease in purification and environmentally benign methodology. The reaction conditions were optimized employing Response Surface Method technique (Central Composite Design (CCD)) which is economically considerable because of the minimum number of experiments required to evaluate the effects of multiple parameters on the response. |
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| Keywords: | 1,4‐dihydropyridines Nano‐WO3‐supported sulfonic acid Heterogeneous catalysis Solvent‐free Hantzsch reaction Response surface method |
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