Polyketides and Meroterpenoids from Neosartorya glabra |
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| Authors: | Wen‐Hong Liu Hong Zhao Rong‐Qun Li Hong‐Bin Zheng Qin Yu |
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| Affiliation: | 1. College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P.?R. China (phone/fax: +86‐571‐86613712);2. First Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou 310053, P.?R. China;3. College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, P.?R. China |
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| Abstract: | Two new polyketides, neosarphenols A and B ( 1 and 2 , resp.), were isolated from Neosartorya glabra, together with six known polyketides, 3 – 8 , and two meroterpenoids, 9 and 10 . The structures of the new compounds were elucidated by comprehensive spectroscopic analysis, especially by HR‐ESI‐MS and NMR experiments. All compounds were evaluated for their cytotoxic activities against MDA‐MB‐231, MCF‐7, and PANC‐1 tumor cell lines; 1 and 6 exhibited selective and moderate cytotoxicities against PANC‐1 cell line. |
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| Keywords: | Polyketides Neosarphenols A and B Neosartorya glabra Meroterpenoids Cytotoxic activity |
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