Copper/Graphene/Clay Nanohybrid: A Highly Efficient Heterogeneous Nanocatalyst for the Synthesis of Novel 1,2,3‐Triazolyl Carboacyclic Nucleosides via ‘Click’ Huisgen 1,3‐Dipolar Cycloaddition |
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| Authors: | Mohammad Navid Soltani Rad Somayeh Behrouz S. Jafar Hoseini Hasan Nasrabadi Maryam Saberi Zare |
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| Affiliation: | 1. Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, Shiraz 71555‐313, Iran, (phone: +98‐71‐37261392;2. fax: +98‐71‐37354523);3. Department of Chemistry, Faculty of Sciences, Yasouj University, Yasouj 7591874831, Iran |
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| Abstract: | A very mild and highly efficient synthesis of some novel 1H‐1,2,3‐triazolyl carboacyclic nucleosides via a ‘Click’ Huisgen cycloaddition of N‐propargyl nucleobases and azido alcohols using Cu/aminoclay/reduced graphene oxide nanohybrid (Cu/AC/r‐GO nanohybrid) as nanocatalyst is described. The preparation and characterization of Cu/AC/r‐GO nanohybrid are discussed. This catalyst was characterized by X‐ray diffraction, FT‐IR, TEM, and energy‐dispersive analysis of X‐ray techniques. Cu/AC/r‐GO nanohybrid is a stable and highly efficient heterogeneous nanocatalyst that can be easily prepared, used, and restored from the reaction mixture by simple filtration, and reused for many consecutive trials without significant decrease in activity. |
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| Keywords: | ‘ Click’ reaction Heterogeneous catalysts Huisgen cycloaddition Nanohybrids 1H‐1,2,3‐Triazolyl carboacyclic nucleosides |
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