Copper‐Catalyzed Difunctionalization of Activated Alkynes by Radical Oxidation–Tandem Cyclization/Dearomatization to Synthesize 3‐Trifluoromethyl Spiro[4.5]trienones |
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| Authors: | Dr. Hui‐Liang Hua Yu‐Tao He Yi‐Feng Qiu Ying‐Xiu Li Bo Song Pin Gao Xian‐Rong Song Dong‐Hui Guo Prof. Dr. Xue‐Yuan Liu Prof. Dr. Yong‐Min Liang |
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| Affiliation: | State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (P. R. China), Fax: (+86)?931‐891‐2582 |
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| Abstract: | A copper‐catalyzed difunctionalizing trifluoromethylation of activated alkynes with the cheap reagent sodium trifluoromethanesulfinate (NaSO2CF3 or Langlois’ reagent) has been developed incorporating a tandem cyclization/dearomatization process. This strategy affords a straightforward route to synthesis of 3‐(trifluoromethyl)‐spiro[4.5]trienones, and presents an example of difunctionalization of alkynes for simultaneous formation of two carbon–carbon single bonds and one carbon–oxygen double bond. |
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| Keywords: | copper cyclization radical reactions tandem reactions trifluoromethylation |
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