Synthetic Studies on Actinorhodin and γ‐Actinorhodin: Synthesis of Deoxyactinorhodin and Deoxy‐γ‐actinorhodin/Crisamicin A Isomer |
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| Authors: | Sandip V. Mulay Prof. Dr. Rodney A. Fernandes |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, Maharashtra (India) |
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| Abstract: | A strategy based on bidirectional Dötz benzannulation and the oxa‐Pictet–Spengler reaction toward the synthesis of actinorhodin and γ‐actinorhodin has been explored. This work has resulted in the synthesis of deoxyactinorhodin and deoxy‐γ‐actinorhodin. The latter is a regioisomer of crisamicin A (which has 10,10′‐dihydroxy groups). |
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| Keywords: | actinorhodins annulation bidirectional synthesis pyranonaphthoquinones synthetic methods |
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