Thermal apoptosis analysis considering injection behavior optimization and mass diffusion during magnetic hyperthermia |
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| Authors: | Yun-Dong Tang Jian Zou Rodolfo C C Flesch Tao Jin Ming-Hua He |
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| Affiliation: | 1.College of Physics and Information Engineering, Fuzhou University, Fuzhou 350116, China;2.Departamento de Automação e Sistemas, Universidade Federal de Santa Catarina, 88040-900 Flórianopolis, SC, Brazil;3.College of Electrical Engineering and Automation, Fuzhou University, Fuzhou 350108, China;4.Fujian Medical University, Fuzhou 350122, China |
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| Abstract: | Thermally induced apoptosis for tumors depends mainly on the intrinsic characteristics of biological tissues as well as treatment temperature profile during magnetic hyperthermia. Further, treatment temperature distribution inside tumor depends on the injection behavior of irregular tumors, such as the injection dose and the injection location of nanofluids. In order to improve the treatment effect, the simulated annealing algorithm is adopted in this work to optimize the nanofluid injection behavior, and the improved Arrhenius model is used to evaluate the malignant ablations for three typical malignant tumor cell models. In addition, both the injection behavior optimization and the mass diffusion of nanofluid are both taken into consideration in order to improve the treatment effect. The simulation results demonstrate that the injection behavior can be optimized effectively by the proposed optimization method before therapy, the result of which can also conduce to improving the thermal apoptosis possibility for proposed typical malignant cells. Furthermore, an effective approach is also employed by considering longer diffusion duration and correct power dissipation at the same time. The results show that a better result can then be obtained than those in other cases when the power dissipation of MNPs is set to be QMNP=5.4×107W·m3 and the diffusion time is 16 h. |
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| Keywords: | thermal apoptosis analysis injection behavior optimization mass diffusion magnetic hyperthermia |
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