Atom‐Economic Silver‐Catalyzed Difunctionalization of the Isocyano Group with Cyclic Oximes: Towards Pyrimidinediones |
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| Authors: | Hong‐Wen Liang Zhen Yang Kun Jiang Ying Ye Prof. Dr. Ye Wei |
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| Affiliation: | College of Pharmacy, Third Military Medical University, Chongqing, China |
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| Abstract: | An unprecedented silver‐catalyzed difunctionalization of the isocyano group with cyclic oximes is described. This method allows efficient and atom‐economic assembly of a vast array of structurally novel and interesting pyrimidinediones, and tolerates a range of functionalities. The resulting products can be easily converted into some useful compounds. Furthermore, the method can also be applied for the late‐stage modification of a few biologically active molecules. |
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| Keywords: | homogeneous catalysis isocyanides N-heterocycles oximes silver |
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