Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis |
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| Authors: | Koji Kubota Keiichi Hayama Hiroaki Iwamoto Prof. Dr. Hajime Ito |
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| Affiliation: | Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Kita 13 Nishi 8 Kita‐ku, Sapporo, Hokkaido 060‐8628 (Japan) |
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| Abstract: | The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction involves the regio‐ and enantioselective addition of active borylcopper(I) species to indole‐2‐carboxylates, followed by the diastereoselective protonation of the resulting copper(I) enolate to give the corresponding chiral indolines, which bear consecutive stereogenic centers. |
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| Keywords: | borylation copper dearomatization enantioselective synthesis indoles |
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