Self‐Assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery |
| |
| Authors: | Hui Wang Yitong Wang Yu Wang Jingjing Hu Tianfu Li Hongmei Liu Qiang Zhang Yiyun Cheng |
| |
| Affiliation: | 1. Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai (China);2. Changzheng Hospital, Department of Orthopedic Oncology, Shanghai (China);3. China Institute of Atomic Energy, Beijing (China) |
| |
| Abstract: | An ideal vector in gene therapy should exhibit high serum stability, excellent biocompatibility, a desired transfection efficacy and permeability into targeted tissues. Here, we describe a class of low‐molecular‐weight fluorodendrimers for efficient gene delivery. These materials self‐assemble into uniform nanospheres and allow for efficient transfection at low charge ratios and very low DNA doses with minimal cytotoxicity. Our results demonstrate that these vectors combine the features of synthetic gene vectors such as liposomes and cationic polymers and present promising potential for clinical gene therapy. |
| |
| Keywords: | dendrimers fluorine gene delivery self‐assembly |
|
|
