| 5-氟尿嘧啶自旋标记衍生物的合成及其抗肿瘤活性研究 |
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| 引用本文： | 毛曼君,田瑄,陈耀祖. 5-氟尿嘧啶自旋标记衍生物的合成及其抗肿瘤活性研究[J]. 高等学校化学学报, 1998, 19(3): 395-398 |
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| 作者姓名： | 毛曼君 田瑄 陈耀祖 |
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| 作者单位： | 1. 中国科学院兰州地质所, 兰州, 730000;2. 兰州大学化学系, 兰州, 730000 |
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| 摘 要： | 将4种稳定氮氧自由基引入5-氟尿嘧啶,合成了10个新的5-氟尿嘧啶(Fu)自旋标记衍生物2a-8.经元素分析、IR、UV、MS和ESR确定了其组成和结构.化合物对KB、HCT-8和A 2780细胞毒性实验结果表明,化合物2a和3a的抗癌活性高于5-Fu,与HCFU的活性相当.
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| 关 键 词： | 5-氟尿嘧啶 自旋标记 氮氧自由基 抗肿瘤活性 |
| 收稿时间： | 1997-01-21 |
Syntheses and Antitumor Activities of Spin-labeled 5-Fluorouracil Derivatives |
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| MAO Man-Jun,TIAN Xuan,CHEN Yao-Zu. Syntheses and Antitumor Activities of Spin-labeled 5-Fluorouracil Derivatives[J]. Chemical Research In Chinese Universities, 1998, 19(3): 395-398 |
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| Authors: | MAO Man-Jun TIAN Xuan CHEN Yao-Zu |
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| Affiliation: | 1. Lanzhou Institute of Geology, Chinese Academy of Sciences, Lanzhou, 730000;2. Department of Chemistry, Lanzhou University, Lanzhou, 730000 |
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| Abstract: | Ten new spin labeled derivatives of 5 fluorouracil(2a_8) were synthesized by introducing four kinds of stable nitroxyl radicals into N 1 and N 3 site of 5 Fu. The structures of these new compounds were confirmed by IR, UV, MS, ESR spectra and elemental analysis. The antitumor activities of these compounds were tested to be against KB, HCT 8 and A2780. The preliminary results showed that the antitumor activities of compounds 2a and 3a were stronger than that of 5 Fu and were similar to that of HCFU. |
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| Keywords: | Fluorouracil Spin label Nitroxyl radical Antitumor activity |
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