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Asymmetric Dual‐Reagent Catalysis: Mannich‐type Reactions Catalyzed by Ion Pair |
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| Authors: | Hong‐Yu Wang Kai Zhang Dr. Chang‐Wu Zheng Dr. Zhuo Chai Dong‐Dong Cao Jia‐Xing Zhang Prof. Gang Zhao |
| Affiliation: | 1. Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P.R. China);2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, 200032 (P.R. China) |
| Abstract: | The combination of a new bifunctional phosphine and an acrylate generate a zwitterion in situ and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion‐pairing mode. This new catalytic system has been successfully applied to Mannich‐type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented. |
| Keywords: | asymmetric synthesis fluorine imines organocatalysis phosphines |