The Catalytic Asymmetric Abramov Reaction |
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| Authors: | Dr. Joyram Guin Dr. Qinggang Wang Manuel van Gemmeren Prof. Dr. Benjamin List |
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| Affiliation: | Max‐Planck‐Institut für Kohlenforschung, Kaiser Wilhelm‐Platz 1, 45470 Mülheim an der Ruhr (Germany) |
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| Abstract: | The first catalytic enantioselective Abramov reaction is described. The process is based on the utilization of a chiral disulfonimide catalyst, which efficiently avoids the difficulties encountered with metal‐based catalysts. Several functionalized α‐hydroxy phosphonates were synthesized in good yields and with excellent enantiomeric ratios of up to >99:1. The process was shown to be scalable and up to 1 g of starting material could be employed under mild reaction conditions. |
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| Keywords: | Abramov reaction disulfonimides hydrophosphonylations organocatalysis α ‐hydroxy phosphonates |
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