A Self‐Reporting Photocatalyst for Online Fluorescence Monitoring of High Throughput RAFT Polymerization |
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| Authors: | Dr. Jonathan Yeow Dr. Sanket Joshi Dr. Robert Chapman Prof. Cyrille Boyer |
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| Affiliation: | 1. Centre for Advanced Macromolecular Design, UNSW, Sydney, Australia;2. Australian Centre for Nanomedicine, School of Chemical Engineering, UNSW, Sydney, Australia;3. ACRF Drug Discovery Centre for Childhood Cancer, Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, The University of New South Wales Australia, Sydney, NSW, Australia |
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| Abstract: | Translating controlled/living radical polymerization (CLRP) from batch to the high throughput production of polymer libraries presents several challenges in terms of both polymer synthesis and characterization. Although recently there have been significant advances in the field of low volume, high throughput CLRP, techniques able to simultaneously monitor multiple polymerizations in an “online” manner have not yet been developed. Here, we report our discovery that 5,10,15,20‐tetraphenyl‐21H,23H‐porphine zinc (ZnTPP) is a self‐reporting photocatalyst that can mediate PET‐RAFT polymerization as well as report on monomer conversion via changes in its fluorescence properties. This enables the use of a microplate reader to conduct high throughput “online” monitoring of PET‐RAFT polymerizations performed directly in 384‐well, low volume microtiter plates. |
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| Keywords: | online monitoring PET-RAFT photochemistry polymerization |
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