Copper(I)‐Catalyzed Enantio‐ and Diastereodivergent Borylative Coupling of Styrenes and Imines |
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| Authors: | Dr. Taisuke Itoh Yamato Kanzaki Dr. Yohei Shimizu Prof. Dr. Motomu Kanai |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan |
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| Abstract: | We report copper(I)‐catalyzed enantio‐ and diastereodivergent borylative coupling of styrenes and imines to produce enantiomerically‐enriched α,β‐dibranched γ‐boryl amine derivatives. Each of the four possible stereoisomers of the products, derived from the two contiguous stereocenters, was selectively accessible by choosing a proper chiral ligand for the copper catalyst. This method, which combines catalyst‐controlled stereodivergency and constitutional divergency derived from the lynchpin motif (i.e., the C?B bond), offers a strategy for addressing the construction of molecular structural diversity concomitant with precise chirality control. |
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| Keywords: | asymmetric catalysis borylation chiral amines difunctionalization stereodivergent reaction |
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