Tandem Gold/Silver‐Catalyzed Cycloaddition/Hydroarylation of 7‐Aryl‐1,6‐enynes to Form 6,6‐Diarylbicyclo[3.2.0]heptanes |
| |
| Authors: | Bradley D. Robertson Rachel E. M. Brooner Prof. Ross A. Widenhoefer |
| |
| Affiliation: | French Family Science Center, Duke University, Durham, NC 27708–0346 (USA) |
| |
| Abstract: | Mixtures of [{PCy2(o‐biphenyl)}AuCl] and AgSbF6 catalyze the tandem cycloaddition/hydroarylation of 7‐aryl‐1,6‐enynes with electron‐rich arenes to form 6,6‐diarylbicyclo[3.2.0]heptanes in good yield under mild conditions. Experimental observations point to a mechanism involving gold‐catalyzed cycloaddition followed by silver‐catalyzed hydroarylation of a bicyclo[3.2.0]hept‐1(7)‐ene intermediate. |
| |
| Keywords: | aromatic substitution cycloaddition enynes gold silver |
|
|
