| 碱退式辅酶B~1~2类似物的合成和光谱性质 |
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| 引用本文： | 罗来斌,燕红,陈慧兰,唐雯霞. 碱退式辅酶B~1~2类似物的合成和光谱性质[J]. 化学学报, 1996, 54(10): 1030-1036 |
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| 作者姓名： | 罗来斌 燕红 陈慧兰 唐雯霞 |
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| 作者单位： | 南京大学化学系;南京大学配位化学国家重点实验室 |
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| 基金项目： | 国家自然科学基金，江苏省自然科学基金资助的课题 |
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| 摘 要： | 本工作用改进的方法合成了一类新的辅酶B~1~2碱退式类似物-含2'-脱氧核苷钴啉醇酰胺。它们分别是2',5'-二脱氧尿苷钴啉醇酰胺(2'dUrdCbi), 2',5'-二脱氧腺苷钴啉醇酰胺(2'dAdoCbi), 2',5'-二脱氧胞苷钴啉醇酰胺(2'dCytCbi)以及5'-脱氧胸苷钴啉醇酰胺(ThyCbi)。研究了它们的UV-Vis和^1H NMR光谱性质。并且和相应钴胺素的有关性质作了比较。
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| 关 键 词： | 类似物 光谱性质 脱氧核苷 其它基金 辅酶B~1~2 钴啉醇酰胺 |
Synthesis and spectroscopic properties of coenzyme B~1~2 base-off form analogues |
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| LUO LAIBIN,YAN HONG,CHEN HUILAN,TANG WENXIA. Synthesis and spectroscopic properties of coenzyme B~1~2 base-off form analogues[J]. Acta Chimica Sinica, 1996, 54(10): 1030-1036 |
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| Authors: | LUO LAIBIN YAN HONG CHEN HUILAN TANG WENXIA |
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| Abstract: | A new kind of analogues of coenzyme B~1~2 base-off form, which are cobinamides containing 2'-deoxynucleosides, were synthesized by an improved method. They are 2',5'-dideoxyuridinylcobinamide, 2',5'- dideoxyadenosylcobinamide, 2',5'-dideoxycytidylcobinamide, and 5'- deoxythymidylcobinamide. All the four analogues were investigated by UV-Vis and 2D ^1H NMR spectroscopies. The spectroscopic properties with those of their corresponding cobalamins were compared. |
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| Keywords: | ANALOGUE SPECTRAL PROPERTIES DEOXYRIBONUCLEOSIDE COBINAMIDE |
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