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Metal‐Free [2+2+2] Cycloaddition of Ynamides and Nitriles: Mild and Regioselective Synthesis of Fully Substituted Pyridines |
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| Authors: | Yong Wang Li‐Juan Song Prof. Xinhao Zhang Prof. Jianwei Sun |
| Affiliation: | 1. Department of Chemistry, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong SAR, China;2. HKUST Shenzhen Research Institute, Shenzhen, China;3. Lab of Computational Chemistry and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China |
| Abstract: | A metal‐free trimolecular [2+2+2] cycloaddition of internal ynamides and nitriles for de novo synthesis of fully substituted pyridines is disclosed. With the versatile Brønsted acid catalyst HNTf2, the mild intermolecular cyclotrimerization process proceeds with complementary chemoselectivity and excellent regioselectivity. |
| Keywords: | Brø nsted acid cycloaddition cyclotrimerization heterocycles reaction mechanisms |