| p53基因转导联合放射治疗恶性肿瘤的研究进展 |
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| 引用本文： | 段昕,张红. p53基因转导联合放射治疗恶性肿瘤的研究进展[J]. 原子核物理评论, 2006, 23(3): 326-330. DOI: 10.11804/NuclPhysRev.23.03.326 |
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| 作者姓名： | 段昕 张红 |
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| 作者单位： | [1]中国科学院近代物理研究所,甘肃兰州730000 [2]中国科学院研究生院,北京100049 |
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| 基金项目： | 中国科学院"百人计划" |
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| 摘 要： | 肿瘤治疗是目前医学研究的重点方向，其方法包括传统的放疗、化疗、手术以及目前热门的各种基因治疗等，各有其优缺点。而p53基因治疗与放射治疗方法的结合越来越受到重视。综述了近年来p53基因转导联合放射治疗恶性肿瘤的研究结果以及可能的作用机理及进展。Cancer treatment is one of the most important fields in medical research. All strategies such as radiotherapy, chemotherapy, surgery, and gene-based therapy have their own advantages and disadvantages. Nowadays, a novel method which combined p53-gene therapy with radiotherapy plays an important role in the field of cancer research. This review summarized the current state of combined therapies of p53-genetherapy and radiotherapy, possible mechanism and recent progress.
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| 关 键 词： | p53基因 基因治疗 放射治疗 重离子 恶性肿瘤 |
| 文章编号： | 1007-4627（2006）03-0326-05 |
| 收稿时间： | 2005-12-19 |
| 修稿时间： | 2006-04-12 |
Status and Advances of p53-Genetherapy and Radiotherapy in Malignant Tumer |
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| DUAN Xin,ZHANG Hong. Status and Advances of p53-Genetherapy and Radiotherapy in Malignant Tumer[J]. Nuclear Physics Review, 2006, 23(3): 326-330. DOI: 10.11804/NuclPhysRev.23.03.326 |
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| Authors: | DUAN Xin ZHANG Hong |
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| Affiliation: | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China ; 2.Graduate School of Chinese Academy of Sciences, Beifing 100049, China |
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| Abstract: | Cancer treatment is one of the most important fields in medical research.All strategies such as radiotherapy,chemotherapy,surgery,and gene-based therapy have their own advantages and disadvantages.Nowadays,a novel method which combined p53-gene therapy with radiotherapy plays an important role in the field of cancer research.This review summarized the current state of combined therapies of p53-genetherapy and radiotherapy,possible mechanism and recent progress. |
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| Keywords: | p53 gene gene therapy radiotherapy heavy ion malignant tumor |
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